Menopause is defined by a decline in estrogen (particularly estradiol) Ā and other sex steroids, which affects metabolism, body composition, cardiovascular health, bone density, and many systems throughout the body. Lower estrogen is linked with: Increased visceral fat and reduced muscle mass (changing metabolic rate). Higher risk of bone loss, osteoporosis, and cardiovascular disease. Changes in lipid metabolism and inflammatory profiles. Because hormones influence many pathw